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A shortcoming of register data is the lack of surgery-relatedrisk factors, such as duration of surgery or timing of antibiotic prophylaxis [77, 78].

An example of the use of the TeF approach is therisk assessment of polyhalogenated aromatic compounds.Most of the adverse health effects of concern for thesecompounds are thought to arise from a common mode oftoxicity: Ah receptor activation. These metabolites are mostly conjuga-ted with glucuronic acid or sulfate before excre-tion in urine. Inhalers and oral medications are bothtraditional therapies for asthma

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